Faculty
Faculty / Wipawee Winuthayanon

Dr. Wipawee "Joy" Winuthayanon

Assistant Professor

winuthayanonw@vetmed.wsu.edu

Office
Room: BLS 239
Phone: 509-335-8296

Pages

Wipawee

Research and Interests

Approximately 50-80 million reproductive age couples worldwide suffer from infertility. These couples encounter psychological distress, including low self-esteem, isolation, and depression; emphasizing the need for a better understanding the causes of infertility. At Winuthayanon Lab, we focus on studying how ovarian steroid hormones (estrogen and progesterone) affect fertility during sperm and embryo transport within the female reproductive tract. There are multiple components of the cells in female reproductive tract that work in concert to provide optimal microenvironment for gametes (eggs and sperm) and the embryos to establish successful pregnancy. In our lab, we use genetic engineered mouse models to dissect the molecular mechanisms and functional requirement of estrogen and estrogen signals during pregnancy. Our research aims to provide basic knowledge in reproductive biology during early pregnancy as well as potential targets for contraceptive agents and therapeutic approaches for infertility.

Winuthayanon infographic

Publications

All Publications
  • Hewitt SC, Winuthayanon W, and Korach KS. (2016) What’s new in estrogen receptor action in the female reproductive tract. J Mol Endocrin. 56: R55-71.

  • Winuthayanon W, Bernhardt ML, Padilla-Banks E, Myers PH, Edin ML, Lih F, Korach KS, and Williams CJ. (2015) Oviductal estrogen receptor α signaling prevents protease-mediated embryo death. eLIFE. 4:e10453.

    * Highlighted in World of Reproductive Biology: The Inconstant Oviduct, Dec 2015
    * NIEHS paper of the month, Feb 2016
  • Binder AK, Winuthayanon W, Hewitt SC, Couse JF, and Korach, KS. Steroid Receptors in the Ovary and Uterus. In: Plant TM and Zeleznik AJ (eds.), Knobil and Neill’s Physiology of Reproduction, vol. 1, 4th ed. London: Elsevier; 2015: 1099-193.

  • Hewitt SC, Winuthayanon W, Pockette B, Kerns RT, Suksamrarn A, Piyachaturawat P, Bushel PR, Korach KS. (2015) Development of phenotypic and transcriptional biomarkers to establish activity and potency of candidate xenoextrogens. Environ Health Perspect. 123: 334-52.

  • Winuthayanon W, Hewitt SC, and Korach KS. (2014) Uterine epithelial cell Estrogen Receptor α –dependent and –independent genomic profiles that underlie estrogen response. Biol Reprod. 95:110, 1-10.

    * NIEHS paper of the month, Feb 2015
  • Hewitt SC, Li L, Grimm SA, Winuthayanon W, Hamilton KJ, Pockette B, Rubel CA, Pedersen LC, Fargo D, Lanz RB, DeMayo FJ, Schütz G, Korach KS. (2014) Novel DNA Motif Binding Activity Observed in vivo with an ERα Mutant Mouse. Mol Endo. 28: 899-911.

  • Winuthayanon W, Piyachaturawat P, Suksamrarn A, Arao Y, Burns KA, Hewitt SC, Pedersen LC, and Korach KS. (2013) Natural Estrogenic Compound Diarylheptanoid (D3): In vitro Mechanisms of Action and In Vivo Uterine Responses via Estrogen Receptor α. Environ Health Perspect. 121:433-9.

    * NIEHS paper of the month, Jun 2013
  • Winuthayanon W, Hewitt SC, Orvis GD, Behringer RR, and Korach KS. (2010) Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses. Proc Natl Acad Sci USA. 107: 19272-7.

    * Post-publication peer reviewed recognition in F1000 as “must read paper”, Nov 2010
    * NIEHS paper of the month, Jan 2011
  • Winuthayanon W, Piyachaturawat P, Suksamrarn A, Ponglikitmongkol M, Arao Y, Hewitt SC, and Korach KS. (2009) Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms. Environ Health Perspect. 117: 1155-61.

  • Winuthayanon W, Suksen K, Boonchird C, Chuncharunee A, Ponglikitmongkol M, Suksamrarn A, Piyachaturawat P. (2009) Estrogenic activity of diarylheptanoids from Curcuma comosa Roxb. requires metabolic activation. J Agric Food Chem. 57: 840-5.

  • Deroo BJ, Burns KA, Winuthayanon W, and Korach, KS. (2009) Potential effects for environmental xeno-oestrogens: Pollution and fertility. The Biochemist. 31: 22-6.